FOOT-AND-MOUTH DISEASE OIL VACCINES WITH OR WITHOUT ALUMINUM HYDROXIDE CONCENTRATION OF ANTIGEN: IMMUNE RESPONSE IN VACCINATED CATTLE
Abstract
The immune response of three different formulations of foot-and-mouth disease (FMD) oil vaccines in vaccinated cattle was compared. The vaccines used were: 1) standard oil vaccine (VOR) without aluminum hydroxide; 2) VOR with aluminum hydroxide (VOAI) and 3) oil vaccine containing antigen 10x concentrated by aluminum hydroxide (V010x). Each vaccine was used in a group of 9 animais, and each animal received a 5m1 dose of vaccine by intramuscular rouco. Neutralizing antibodies were evaluated by vírus neutralization test (VN) at day 0 and at 30, 90 and 180 days post vaccination. All animais were shown previously to be free of either neutralizing or anti-VIA (vira) infection associated antigen) antibodies and were considered to be susceptible to FMD. Serology for anti-VIA antibodies was carried out and the tests were negativo during the experiment. The results obtained showed that concentrating antigen (10x) was not enough to increase significantly (P>0.05) the leveis of neutralizing antibodies, and also that the aluminum hydroxide (HAI) included in VOR did not increase significantly the levei of these antibodies. Antigen concentration (10x) plus the addition of HAI increased significantly (P<0.05) the antibody levels of vaccinated animais.
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